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The key metabolite, hydrogen selenide, is formed from inorganic sodium selenite via selenoglutathione through reduction by thiols and NADPH-dependent reductase

L-alanine is primarily used as a substrate for nascent protein production, whereas L-arginine availability shapes cellular fitness and viability 71,72

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For example, oncolytic adenoviruses and herpes simplex viruses have been engineered to selectively replicate within CSCs, leading to tumor cell lysis and the activation of antitumor immune responses

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